Creatinine Clearance Calculator: Assess Your Kidney Function
The kidneys filter waste from your blood at a rate that reflects their functional capacity. Creatinine Clearance (CrCl), calculated using the Cockcroft-Gault equation, estimates this filtration rate from a serum creatinine blood test โ and is widely used for drug dosing in patients with kidney disease.
The Cockcroft-Gault Formula
CrCl (mL/min) = [(140 โ Age) ร Weight (kg)] รท (72 ร Serum Creatinine mg/dL)
Multiply by 0.85 for females
Worked Example
Female, 65 years old, 60 kg, serum creatinine 1.1 mg/dL.
CrCl = [(140โ65) ร 60] รท (72 ร 1.1) = 4500 รท 79.2 = 56.8 ร 0.85 = 48.3 mL/min (Mild-Moderate decrease)
Calculate your CrCl with our Creatinine Clearance Calculator.
CKD Stage Classification
| CrCl / eGFR (mL/min) | CKD Stage | Kidney Function |
| 90+ | Stage 1 (if markers present) | Normal or high |
| 60โ89 | Stage 2 | Mildly decreased |
| 30โ59 | Stage 3 | Moderately decreased |
| 15โ29 | Stage 4 | Severely decreased |
| Below 15 | Stage 5 | Kidney failure โ dialysis |
Clinical Use in Drug Dosing
CrCl from the Cockcroft-Gault equation is the standard used to adjust doses of renally-cleared drugs including antibiotics, diabetes medications (metformin, SGLT-2 inhibitors), blood thinners (apixaban, dabigatran), and many others. Using the wrong dose in kidney disease can cause drug toxicity.
Practical Tips
Serum creatinine alone is misleading. A muscle-wasted elderly person may have a "normal" creatinine (0.7 mg/dL) but actually poor kidney function โ because less creatinine is produced from reduced muscle mass. CrCl corrects for this by including age and weight.
Get kidney function checked annually if you have hypertension, diabetes, or cardiovascular disease โ the main causes of chronic kidney disease.
Final Thoughts
Creatinine clearance is essential for safe drug prescribing and for monitoring kidney disease progression. Understanding your result helps you have informed conversations with your doctor.
Calculate your kidney function with our free Creatinine Clearance Calculator.